Nearby Interactions
γGI Heatmap
Gene list must be unified across datasets to display plot.
τGI Heatmap
Gene list must be unified across datasets to display plot.
νGI Heatmap
Gene list must be unified across datasets to display plot.
FAQ
What do gamma (γ), tau (τ), rho (ρ), and nu (ν) mean?
These indicate the different measurements made in our screen. Gamma refers to growth-based measurements made in the reference (control) arm, tau to those made in the PARPi-treated arm, and rho phenotypes describe drug sensitization by normalizing the PARPi-treated arm to the reference arm. Finally, nu GI scores are the difference between tau and gamma GI scores.
What are poor object sgRNAs?
When analyzing our data, we found a set of sgRNAs which generated unreliable GI scores when they appeared as an object in other sgRNA models. These sgRNAs can be highlighted on relevant plots.
What are lists?
Up to 5 gene lists can be saved each session for heatmap visualization. Genes can be saved to lists by using the 'Define Gene Subsets' tabs, and lists can be overwritten if needed. Gene lists can be edited and downloaded for future use using the 'View and Edit Saved Lists' tab.
Why are the heatmaps so slow to load?
When large numbers of genes are selected for visualization, the combined work of clustering and plotting takes a little longer to perform; don't worry, your plot should appear within a second or two!
Where can I find more information?
Please refer to our manuscript.
These indicate the different measurements made in our screen. Gamma refers to growth-based measurements made in the reference (control) arm, tau to those made in the PARPi-treated arm, and rho phenotypes describe drug sensitization by normalizing the PARPi-treated arm to the reference arm. Finally, nu GI scores are the difference between tau and gamma GI scores.
What are poor object sgRNAs?
When analyzing our data, we found a set of sgRNAs which generated unreliable GI scores when they appeared as an object in other sgRNA models. These sgRNAs can be highlighted on relevant plots.
What are lists?
Up to 5 gene lists can be saved each session for heatmap visualization. Genes can be saved to lists by using the 'Define Gene Subsets' tabs, and lists can be overwritten if needed. Gene lists can be edited and downloaded for future use using the 'View and Edit Saved Lists' tab.
Why are the heatmaps so slow to load?
When large numbers of genes are selected for visualization, the combined work of clustering and plotting takes a little longer to perform; don't worry, your plot should appear within a second or two!
Where can I find more information?
Please refer to our manuscript.
Downloads
Mapping the Genetic Interaction Network of PARP inhibitor Response
Danny Simpson*, Jia Ling*, Yangwode Jing, Britt Adamson
